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Assessing the effectiveness of statin therapy for

Aug 17, 2020 · Cerebral small vessel disease (CSVD) is an age-related clinical cognitive syndrome encompassing a group of pathological processes with multifarious etiologies that affect the small vessels in the brain [1,2,3,4].Some prominent features associated with CSVD include white matter hyperintensities (WMH), lacunes, enlarged perivascular space (EPVS), and microbleeds observed Cerebral small vessel disease and vascular cognitive Feb 23, 2021 · POTENTIAL PATHOLOGICAL MECHANISMS LINKING SMALL VESSEL DISEASE TO COGNITIVE IMPAIRMENT. Interactions between ageing [], environmental risk factors [11 ] and genetic variants [12,13] are thought to contribute to the development of sporadic SVD (Fig. (Fig.1a). 1 a).In the early pathogenic stages, damage to functional units composed of neurons, endothelial cells,

Frontiers Small Vessel Disease Neurology

Sep 24, 2019 · Introduction. Small vessel disease (SVD) refers to any pathologic process that damages small end arteries, arterioles, venules, and brain capillaries ().Although this condition was described pathologically more than a century ago (), its pervasive nature and its association with clinically relevant conditions have been increasingly appreciated as imaging technologies advanced and became more Heavy Metal-Induced Cerebral Small Vessel Disease Cerebral small vessel disease (CSVD) is an umbrella term used to describe various pathological processes that affect the cerebral small blood vessels and is accepted as a primary contributor in associated disorders, such as dementia, cognitive disabilities, mood disorder, and ischemic, as well as a hemorrhagic stroke. New Treatment Approaches to Modify the Course of

  • Where Are We Now? Current Treatment of CsvdAre New Treatments For Csvd needed?Insights from Csvd-Focused Substudies of Major TrialsEarly Phase Trials to Prevent Csvd ProgressionOther Possible InterventionsHow Can We Optimize Trial Design For Csvd?Conclusions and Future DirectionsFor patients with lacunar stroke, secondary prevention strategies are mostly inferred from studies of ischemic stroke in general, the majority of which did not specifically examine efficacy in lacunar stroke. The only large definitive phase 3 trial to focus exclusively on lacunar stroke patients, with magnetic resonance imaging (MRI) confirmation, is the SPS3 trial (Secondary Prevention of Small Subcortical Strokes) of 3020 patients. This trial showed that long-term dual antiplatelet therapy was not superior to Small vessel disease:mechanisms and clinical implications Small vessel disease is a disorder of cerebral microvessels that causes white matter hyperintensities and several other common abnormalities (eg, recent small subcortical infarcts and lacunes) seen on brain imaging. Despite being a common cause of stroke and vascular dementia, the underlying pathogenesis is poorly understood.

    SmallVessel Disease in the Heart and Brain:Current

    Feb 02, 2019 · Ischemic heart disease (IHD), stroke, and dementia are leading causes of death and disability worldwide, 1, 2 notably affecting aging populations. The public health burden related to chest pain is substantial and the epidemiology of IHD because of largevessel coronary atherosclerosis is well documented. 2 By contrast, the epidemiology of smallvessel disease (SVD) in the heart is less Cerebral small vessel disease and the risk of dementia:A Results:We identified 11 studies on white matter hyperintensities, covert brain infarcts, or cerebral microbleeds with risk of all-dementia or Alzheimer's disease. Pooled analyses showed an association of white matter hyperintensity volume and a borderline association of covert brain infarcts with risk of all-dementia (hazard ratio:1.39 [95% confidence interval:1.00; 1.94], N = 3913, and 1.47 [95%